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| HDA2 | Subunit of the HDA1 histone deacetylase complex; possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance; relocalizes to the cytosol in response to hypoxia (674 aa) | ||||
| RXT3 | Transcriptional regulatory protein RXT3; Component of the Rpd3L histone deacetylase complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress; Belongs to the RXT3 family (294 aa) | ||||
| SRB8 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression (1427 aa) | ||||
| RSC3 | Chromatin structure-remodeling complex protein RSC3; Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; RSC3 has a paralog, RSC30, that arose from the whole genome duplication (885 aa) | ||||
| PHO23 | Transcriptional regulatory protein PHO23; Component of the Rpd3L histone deacetylase complex; involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus shares significant sequence identity with the human candidate tumor suppressor p33-ING1 and its isoform ING3 (330 aa) | ||||
| TAF3 | TFIID subunit (47 kDa); involved in promoter binding and RNA polymerase II transcription initiation; Belongs to the TAF3 family (353 aa) | ||||
| CTI6 | Component of the Rpd3L histone deacetylase complex; relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain (506 aa) | ||||
| SWC3 | SWR1-complex protein 3; Protein of unknown function; component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae; Belongs to the SWC3 family (625 aa) | ||||
| SWP82 | SWI/SNF global transcription activator complex subunit SWP82; Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions; Belongs to the RSC7/SWP82 family. SWP82 subfamily (623 aa) | ||||
| DOG2 | 2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed; DOG2 has a paralog, DOG1, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae (246 aa) | ||||
| RFM1 | Repression factor of MSEs protein 1; Component of the Sum1p-Rfm1p-Hst1p complex; Rfm1p tethers the Hst1p histone deacetylase to the DNA-binding protein Sum1p; complex is involved in transcriptional repression of middle sporulation genes and in initiation of DNA replication (310 aa) | ||||
| TFC8 | Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90 (588 aa) | ||||
| AHC2 | Component of the ADA histone acetyltransferase complex; Ahc2p and Ahc1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ahc1p to the complex (128 aa) | ||||
| ARP5 | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; promotes nucleosome shifts in the 3 prime direction; Belongs to the actin family (755 aa) | ||||
| LYS14 | Lysine biosynthesis regulatory protein LYS14; Transcriptional activator involved in regulating lysine biosynthesis; involved in the regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer (790 aa) | ||||
| RPN14 | 26S proteasome regulatory subunit RPN14; Evolutionarily conserved 19S regulatory particle assembly-chaperone; proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p (417 aa) | ||||
| ARP6 | Actin-like protein ARP6; Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A (438 aa) | ||||
| VPS72 | Vacuolar protein sorting-associated protein 72; Htz1p-binding component of the SWR1 complex; exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; may function as a lock that prevents removal of H2AZ from nucleosomes; required for vacuolar protein sorting (795 aa) | ||||
| RXT2 | Transcriptional regulatory protein RXT2; Component of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth; relocalizes to the cytosol in response to hypoxia (430 aa) | ||||
| IOC4 | ISWI one complex protein 4; Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing (475 aa) | ||||
| YDL012C | Cysteine-rich and transmembrane domain-containing protein YDL012C; Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication; Belongs to the CYSTM1 family (107 aa) | ||||
| DOG1 | 2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed; DOG1 has a paralog, DOG2, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae (246 aa) | ||||
| EAF7 | Chromatin modification-related protein EAF7; Subunit of the NuA4 histone acetyltransferase complex; NuA4 acetylates the N-terminal tails of histones H4 and H2A; Belongs to the EAF7 family (425 aa) | ||||
| RSC58 | Chromatin structure-remodeling complex protein RSC58; Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance (502 aa) | ||||
| HIR3 | Histone transcription regulator 3; Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein (1648 aa) | ||||
| IES3 | Subunit of the INO80 chromatin remodeling complex (250 aa) | ||||
| TFC7 | RNA pol III transcription initiation factor complex (TFIIIC) subunit; part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; TFC7 has a paralog, YNL108C, that arose from the whole genome duplication (435 aa) | ||||
| IES5 | Ino eighty subunit 5; Non-essential INO80 chromatin remodeling complex subunit; deletion affects telomere maintenance via recombination (125 aa) | ||||
| SPT21 | Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; localizes to nuclear foci that become diffuse upon DNA replication stress (758 aa) | ||||
| NOT5 | General negative regulator of transcription subunit 5; Component of the CCR4-NOT core complex, involved in mRNA decapping; involved intranscription initiation and elongation and in mRNA degradation; conserved lysine in human homolog of Not5p and Not3p is mutated in cancers (560 aa) | ||||
| PNP1 | Purine nucleoside phosphorylase; specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway; Belongs to the PNP/MTAP phosphorylase family (311 aa) | ||||
| NPL6 | Chromatin structure-remodeling complex subunit RSC7; Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions (435 aa) | ||||
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AHC2 | EAF7 | YCR082W | YNL136W | Component of the ADA histone acetyltransferase complex; Ahc2p and Ahc1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ahc1p to the complex | Chromatin modification-related protein EAF7; Subunit of the NuA4 histone acetyltransferase complex; NuA4 acetylates the N-terminal tails of histones H4 and H2A; Belongs to the EAF7 family | 0.720 |
| AHC2 | SRB8 | YCR082W | YCR081W | Component of the ADA histone acetyltransferase complex; Ahc2p and Ahc1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ahc1p to the complex | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression | 0.808 |
| AHC2 | SWP82 | YCR082W | YFL049W | Component of the ADA histone acetyltransferase complex; Ahc2p and Ahc1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ahc1p to the complex | SWI/SNF global transcription activator complex subunit SWP82; Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions; Belongs to the RSC7/SWP82 family. SWP82 subfamily | 0.656 |
| ARP5 | ARP6 | YNL059C | YLR085C | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; promotes nucleosome shifts in the 3 prime direction; Belongs to the actin family | Actin-like protein ARP6; Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A | 0.922 |
| ARP5 | IES3 | YNL059C | YLR052W | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; promotes nucleosome shifts in the 3 prime direction; Belongs to the actin family | Subunit of the INO80 chromatin remodeling complex | 0.961 |
| ARP5 | IES5 | YNL059C | YER092W | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; promotes nucleosome shifts in the 3 prime direction; Belongs to the actin family | Ino eighty subunit 5; Non-essential INO80 chromatin remodeling complex subunit; deletion affects telomere maintenance via recombination | 0.924 |
| ARP5 | SWC3 | YNL059C | YAL011W | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; promotes nucleosome shifts in the 3 prime direction; Belongs to the actin family | SWR1-complex protein 3; Protein of unknown function; component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae; Belongs to the SWC3 family | 0.900 |
| ARP5 | VPS72 | YNL059C | YDR485C | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; promotes nucleosome shifts in the 3 prime direction; Belongs to the actin family | Vacuolar protein sorting-associated protein 72; Htz1p-binding component of the SWR1 complex; exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; may function as a lock that prevents removal of H2AZ from nucleosomes; required for vacuolar protein sorting | 0.932 |
| ARP6 | ARP5 | YLR085C | YNL059C | Actin-like protein ARP6; Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; promotes nucleosome shifts in the 3 prime direction; Belongs to the actin family | 0.922 |
| ARP6 | EAF7 | YLR085C | YNL136W | Actin-like protein ARP6; Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A | Chromatin modification-related protein EAF7; Subunit of the NuA4 histone acetyltransferase complex; NuA4 acetylates the N-terminal tails of histones H4 and H2A; Belongs to the EAF7 family | 0.403 |
| ARP6 | IES3 | YLR085C | YLR052W | Actin-like protein ARP6; Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A | Subunit of the INO80 chromatin remodeling complex | 0.907 |
| ARP6 | IES5 | YLR085C | YER092W | Actin-like protein ARP6; Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A | Ino eighty subunit 5; Non-essential INO80 chromatin remodeling complex subunit; deletion affects telomere maintenance via recombination | 0.724 |
| ARP6 | SWC3 | YLR085C | YAL011W | Actin-like protein ARP6; Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A | SWR1-complex protein 3; Protein of unknown function; component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae; Belongs to the SWC3 family | 0.984 |
| ARP6 | VPS72 | YLR085C | YDR485C | Actin-like protein ARP6; Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A | Vacuolar protein sorting-associated protein 72; Htz1p-binding component of the SWR1 complex; exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; may function as a lock that prevents removal of H2AZ from nucleosomes; required for vacuolar protein sorting | 0.997 |
| CTI6 | HDA2 | YPL181W | YDR295C | Component of the Rpd3L histone deacetylase complex; relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain | Subunit of the HDA1 histone deacetylase complex; possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance; relocalizes to the cytosol in response to hypoxia | 0.907 |
| CTI6 | PHO23 | YPL181W | YNL097C | Component of the Rpd3L histone deacetylase complex; relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain | Transcriptional regulatory protein PHO23; Component of the Rpd3L histone deacetylase complex; involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus shares significant sequence identity with the human candidate tumor suppressor p33-ING1 and its isoform ING3 | 0.996 |
| CTI6 | RFM1 | YPL181W | YOR279C | Component of the Rpd3L histone deacetylase complex; relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain | Repression factor of MSEs protein 1; Component of the Sum1p-Rfm1p-Hst1p complex; Rfm1p tethers the Hst1p histone deacetylase to the DNA-binding protein Sum1p; complex is involved in transcriptional repression of middle sporulation genes and in initiation of DNA replication | 0.731 |
| CTI6 | RXT2 | YPL181W | YBR095C | Component of the Rpd3L histone deacetylase complex; relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain | Transcriptional regulatory protein RXT2; Component of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth; relocalizes to the cytosol in response to hypoxia | 0.993 |
| CTI6 | RXT3 | YPL181W | YDL076C | Component of the Rpd3L histone deacetylase complex; relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain | Transcriptional regulatory protein RXT3; Component of the Rpd3L histone deacetylase complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress; Belongs to the RXT3 family | 0.995 |
| CTI6 | SRB8 | YPL181W | YCR081W | Component of the Rpd3L histone deacetylase complex; relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression | 0.542 |
