25 items (Canis lupus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

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Your Input:
	ASB4	Ankyrin repeat and SOCS box containing 4 (454 aa)
	NOXA1	NADPH oxidase activator 1 (455 aa)
	NCF4	Neutrophil cytosolic factor 4, 40kDa (339 aa)
	FBXW8	F-box and WD repeat domain containing 8 (601 aa)
	ASB7	Ankyrin repeat and SOCS box containing 7 (318 aa)
	MMP2	Matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); Belongs to the peptidase M10A family (653 aa)
	TRIO	Trio Rho guanine nucleotide exchange factor (3053 aa)
	MAPK14	Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
	PSMC6	Proteasome (prosome, macropain) 26S subunit, ATPase, 6; Belongs to the AAA ATPase family (395 aa)
	NOX3	Uncharacterized protein; Canis lupus familiaris NADPH oxidase 3 (NOX3), mRNA (573 aa)
	WSB2	WD repeat and SOCS box containing 2 (406 aa)
	FBXO21	F-box protein 21 (620 aa)
	UBE2F	Uncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family (185 aa)
	FBXO10	F-box protein 10 (955 aa)
	DCAF10	DDB1 and CUL4 associated factor 10 (564 aa)
	MMP9	Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity) (704 aa)
	COPS8	Uncharacterized protein (209 aa)
	ASB1	Ankyrin repeat and SOCS box containing 1 (323 aa)
	VCAM1	Vascular cell adhesion protein 1; Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation (By similarity) (823 aa)
	NCF2	Canis lupus familiaris neutrophil cytosolic factor 2 (NCF2), mRNA (528 aa)
	NTN1	Netrin 1 (603 aa)
	RAC1	Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated [...] (211 aa)
	ASB18	Ankyrin repeat and SOCS box containing 18 (466 aa)
	CYBA	Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide (195 aa)
	NCF1	Neutrophil cytosolic factor 1 (391 aa)

Your Current Organism:

Canis lupus

NCBI taxonomy Id: 9612
Other names: C. lupus, Canis familiaris, Canis lupus, gray wolf, grey wolf

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASB1	ASB18	ENSCAFP00000018354	ENSCAFP00000017909	Ankyrin repeat and SOCS box containing 1	Ankyrin repeat and SOCS box containing 18	0.927
ASB1	ASB4	ENSCAFP00000018354	ENSCAFP00000003112	Ankyrin repeat and SOCS box containing 1	Ankyrin repeat and SOCS box containing 4	0.922
ASB1	ASB7	ENSCAFP00000018354	ENSCAFP00000015703	Ankyrin repeat and SOCS box containing 1	Ankyrin repeat and SOCS box containing 7	0.937
ASB1	COPS8	ENSCAFP00000018354	ENSCAFP00000038309	Ankyrin repeat and SOCS box containing 1	Uncharacterized protein	0.909
ASB1	FBXO10	ENSCAFP00000018354	ENSCAFP00000003455	Ankyrin repeat and SOCS box containing 1	F-box protein 10	0.902
ASB1	FBXO21	ENSCAFP00000018354	ENSCAFP00000013689	Ankyrin repeat and SOCS box containing 1	F-box protein 21	0.900
ASB1	FBXW8	ENSCAFP00000018354	ENSCAFP00000042791	Ankyrin repeat and SOCS box containing 1	F-box and WD repeat domain containing 8	0.911
ASB1	UBE2F	ENSCAFP00000018354	ENSCAFP00000018202	Ankyrin repeat and SOCS box containing 1	Uncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family	0.911
ASB1	WSB2	ENSCAFP00000018354	ENSCAFP00000014581	Ankyrin repeat and SOCS box containing 1	WD repeat and SOCS box containing 2	0.911
ASB18	ASB1	ENSCAFP00000017909	ENSCAFP00000018354	Ankyrin repeat and SOCS box containing 18	Ankyrin repeat and SOCS box containing 1	0.927
ASB18	ASB4	ENSCAFP00000017909	ENSCAFP00000003112	Ankyrin repeat and SOCS box containing 18	Ankyrin repeat and SOCS box containing 4	0.911
ASB18	ASB7	ENSCAFP00000017909	ENSCAFP00000015703	Ankyrin repeat and SOCS box containing 18	Ankyrin repeat and SOCS box containing 7	0.909
ASB18	COPS8	ENSCAFP00000017909	ENSCAFP00000038309	Ankyrin repeat and SOCS box containing 18	Uncharacterized protein	0.909
ASB18	FBXO10	ENSCAFP00000017909	ENSCAFP00000003455	Ankyrin repeat and SOCS box containing 18	F-box protein 10	0.900
ASB18	FBXO21	ENSCAFP00000017909	ENSCAFP00000013689	Ankyrin repeat and SOCS box containing 18	F-box protein 21	0.900
ASB18	FBXW8	ENSCAFP00000017909	ENSCAFP00000042791	Ankyrin repeat and SOCS box containing 18	F-box and WD repeat domain containing 8	0.911
ASB18	UBE2F	ENSCAFP00000017909	ENSCAFP00000018202	Ankyrin repeat and SOCS box containing 18	Uncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family	0.908
ASB18	WSB2	ENSCAFP00000017909	ENSCAFP00000014581	Ankyrin repeat and SOCS box containing 18	WD repeat and SOCS box containing 2	0.909
ASB4	ASB1	ENSCAFP00000003112	ENSCAFP00000018354	Ankyrin repeat and SOCS box containing 4	Ankyrin repeat and SOCS box containing 1	0.922
ASB4	ASB18	ENSCAFP00000003112	ENSCAFP00000017909	Ankyrin repeat and SOCS box containing 4	Ankyrin repeat and SOCS box containing 18	0.911

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